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E-mini futures on the standard & Poor's 500 index fell 2.27% as dire predictions of more U.S. virus casualties damped sentiment.
The MSCI Asia Pacific stock index, the broadest outside Japan, erased gains and fell 0.33%. Stocks hit by the virus in South Korea fell 1.34%.
Japan equities fell 3.48% on speculation that the government will lock in capital as a result of a rapid increase in the number of people infected in Tokyo.
European futures also suffered, with Stoxx 50 down 2.99%, DAX Germany down 2.89% and FTSE down 3.09%.
Wall Street fell sharply on Tuesday, with the Dow recording its biggest quarterly decline since 1987, while the S & P 500 index recorded its biggest quarterly decline in a decade. There is growing evidence that the pandemic will trigger a massive recession.
Loretta mester, President of the Cleveland Federal Reserve Bank, told CNBC that US economic activity could be "very bad" and unemployment could rise to more than 10 per cent as a result of efforts to curb the spread of the coronavirus.

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